Could a simple blood test reveal our life expectancy?

Study estimates an individual's risk of death from a blood test

A protocol based on plasma proteins

Published in July 2025 in the journal Nature, a study conducted by a research team from Stanford University looked into the possibility of estimating an individual's longevity and predicting their potential age of death based on a blood sample (1). To do this, it analysed 2,916 plasma proteins reflecting organ health and ageing in 44,498 patients aged between 40 and 70, all of whom were registered in the UK Biobank database.

11 organs under the microscope

Using machine learning models, the scientists were able to estimate the biological age of 11 key organs (including the brain, heart, lungs, liver, kidneys and immune tissue), which are supposed to reflect their respective physiological states. It seems fairly logical to believe that a 'biologically advanced' organ is more likely to contract certain pathologies. The researchers therefore set out to determine whether there was a correlation between an individual's risk of mortality and the accelerated ageing of certain organs.

Significant results on mortality risk

The findings show that a person's risk of mortality increases as the number of 'ageing' organs increases. In detail, a subject with a single aged organ has a 1.5 to 3 times greater risk of death. This risk is 2.3 times greater with 2 to 4 aged organs, 4.5 times greater with 5 to 7 aged organs, and 8.3 times greater with 8 or more aged organs. It should be noted that more than 60% of individuals who had 8 extremely old organs at the time of blood sampling died within 15 years.

Brain ageing was also found to be the strongest predictor of mortality. Indeed, it would appear that an aged brain predisposes not only to the onset of neurodegenerative diseases, but also to extracerebral conditions such as COPD or heart failure. This suggests its key role in regulating systemic inflammation and human lifespan.

But the resilience of immunity also counts. Individuals with both a 'young' brain and immune system have seen their risk of mortality significantly reduced. The facts bear this out: over a 17-year period, only 6 out of 160 members of this group died (3.8%), compared with 792 out of 10,000 people of normal age (7.92%).

Estimating life expectancy by blood analysis: limits and promises

This remarkable advance nevertheless comes up against certain limitations. It is based solely on the examination of physiological processes and in no way predicts unforeseen accidents, which are the cause of premature death every year. What's more, the blood test used in this study remains an experimental (and particularly expensive) project, which is not currently prescribed or available in the laboratory.

Nonetheless, monitoring plasma biomarkers is emerging as a promising non-invasive method that would facilitate individual monitoring of our organs and the possible introduction of targeted preventive measures to help us age better and longer.

Ingredients for healthier ageing

In this publication, the researchers also stressed the importance of maintaining regular physical exercise, avoiding alcohol and tobacco, as well as maintaining a balanced diet, rich in poultry and oily fish and low in processed meats. At the same time, certain targeted nutrients, available as supplements, can support the effects of these dietary hygiene measures.

Fisetin: strong senolytic potential

Fisetin is a flavonoid found naturally in certain fruits and vegetables such as apples, strawberries, onions and persimmons. Much studied in recent years by ageing experts, it is thought to have the potential to eliminate the 'senescent' cells that accumulate with age in the organs and end up hindering their proper functioning (2). A study conducted on progeroid mouse models (suffering from accelerated ageing) showed that fisetin significantly reduced senescence markers in numerous tissues and that it acted more effectively than the 9 other flavonoids tested (3).

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Spermidine: the cell protector

Initially discovered in sperm, hence its name, spermidine is found in virtually all living cells. It has been established that this natural polyamine plays a key role in cell growth and maintenance (4). In particular, it is thought to stabilise cell membranes and genetic material, and to be involved in the autophagy process, which 'cleans' cells by ejecting their damaged components (5).

Supplementation with Spermidine provides 3 mg of spermidine per day, the highest level on the market.

Precursors of NAD+: the DNA ‘repairer’

NAD+ (nicotinamide adenine dinucleotide) is a molecule derived from vitamin B3. Present in every cell in our body, it plays a crucial role in energy production, particularly in mitochondrial respiration, but above all in DNA repair by activating enzymes called sirtuins, which guarantee cell longevity (6).

NAD+ levels fall from the age of thirty onwards, which partly explains the resurgence of metabolic disorders with ageing. However, it is possible to boost its production by supplementing with its precursors, choosing between NMN (nicotinamide mononucleotide), which is closer to NAD+ in the conversion chain, and NR (nicotinamide riboside), which has excellent stability (7-8).

For a substantial intake of NMN, opt for Nicotinamide Mononucleotide (125 mg per capsule) or its ultra-concentrated form NMN Max (1,000 mg).

If you prefer to supplement with NR, opt for Nicotinamide Riboside Chloride.

A synergistic super-formula to counter the effects of time

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The important basics for preserving your health

Alongside these exceptional substances, there are still more conventional options for supporting general health. These include vitamin D, which contributes to the normal functioning of the immune system, magnesium, which helps maintain a normal energy metabolism and vitamin B12, which helps reduce fatigue (9-11).

The Daily 3® multivitamin supplement contains no fewer than 45 carefully selected ingredients.

The omega-3 fatty acids EPA and DHA, in addition to their presumed effect on nervous balance and inflammatory response, provide comprehensive protection for the cardiovascular system by ensuring that the heart functions properly and that normal blood pressure and triglyceride levels are maintained (12).

Super Omega 3 combines EPA and DHA in a pure, stable form.

Finally, it is well known that a diet rich in antioxidants helps to protect cells from free radicals: unstable and highly reactive molecules which, when produced in excess, attack their structure, alter some or all of their biological functions and hasten their ageing (13).

AntiOxidant Synergy combines the most renowned compounds in this field: turmeric and bilberry extract with their proven antioxidant properties, as well as green tea, resveratrol, glutathione...